Association of the homeobox transcription factor, ENGRAILED 2, with autism spectrum disorder

@article{Gharani2004AssociationOT,
  title={Association of the homeobox transcription factor, ENGRAILED 2, with autism spectrum disorder},
  author={Neda Gharani and Rym Benayed and vincenzo. mancuso and Linda Brzustowicz and James H. Millonig},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={540-540}
}
Mouse mutants of the homeobox transcription factor Engrailed2 (En2) and autistic individuals display similar cerebellar morphological abnormalities, which include hypoplasia and a decrease in the number of Purkinje cells. Human EN2 maps to 7q36, a chromosomal region that has demonstrated suggestive linkage to autism spectrum disorder (ASD). To investigate EN2 for evidence of association with ASD, four single-nucleotide polymorphisms (SNPs) (rs3735653, rs1861972, rs1861973, rs2361689) that span… CONTINUE READING