Association of the homeobox transcription factor, ENGRAILED 2, with autism spectrum disorder

@article{Gharani2004AssociationOT,
  title={Association of the homeobox transcription factor, ENGRAILED 2, with autism spectrum disorder},
  author={Neda Gharani and Rym Benayed and Vincent Mancuso and Linda Brzustowicz and James H. Millonig},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={540-540}
}
Mouse mutants of the homeobox transcription factor Engrailed2 (En2) and autistic individuals display similar cerebellar morphological abnormalities, which include hypoplasia and a decrease in the number of Purkinje cells.1,2,3,4,5,6,7,8, 9,10,11,12,13,14,15,16, 17,18,19 Human EN2 maps to 7q36, a chromosomal region that has demonstrated suggestive linkage to autism spectrum disorder (ASD).20,21,22 To investigate EN2 for evidence of association with ASD, four single-nucleotide polymorphisms (SNPs… CONTINUE READING

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