Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.

@article{Seidinger2011AssociationOT,
  title={Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.},
  author={Ana Luiza O Seidinger and Maria J Mastellaro and Fernanda Paschoal Fortes and Juliana Godoy Assumpç{\~a}o and Izilda Aparecida Cardinalli and M{\^o}nica Aparecida Ganazza and Raul Correa Ribeiro and S{\'i}lvia Regina Brandalise and Simone dos Santos Aguiar and Jos{\'e} Andr{\'e}s Yunes},
  journal={Cancer},
  year={2011},
  volume={117 10},
  pages={2228-35}
}
BACKGROUND The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a broader range of tumors. Therefore, the authors of this report investigated the spectrum of pediatric malignancies associated with the TP53 R337H mutation at a single referral… CONTINUE READING