Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

@article{Samelson1990AssociationOT,
  title={Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.},
  author={Lawrence E Samelson and Ana Maria Fa{\'i}sca Phillips and E T Luong and Richard D. Klausner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 11},
  pages={4358-62}
}
Activation of the T-cell antigen receptor (TCR) results in tyrosine phosphorylation of the TCR zeta chain and other intracellular substrates. Two other T-cell integral membrane proteins, CD4 and CD8, are associated with the protein-tyrosine kinase (PTK), lck. Despite evidence that activation of this enzyme results in TCR-zeta chain phosphorylation, it has not been shown that the TCR activates lck. We have sought evidence that the TCR is associated with a PTK. In this study we use digitonin to… CONTINUE READING

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The New Biologist 1 , 66 - 74

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