Association of the expression of the glioma-associated oncogene homolog (GLI) 1 with nuclear expression of NF-κB and unfavorable overall survival of patients with pancreatic cancer.

Abstract

4112 Background: Hedgehog signaling pathway is involved in the moleculopathogenesis of pancreatic cancer. In pancreatic cancer, NF-κB up-regulates sonic hedgehog (Shh) expression and further contributes to the activation of hedgehog (Hh) signaling pathway. In this study, we examined the association of Hh signaling pathway with NF-κB activation and clinical… (More)

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