Association of the epithelial sodium channel with Apx and alpha-spectrin in A6 renal epithelial cells.

@article{Zuckerman1999AssociationOT,
  title={Association of the epithelial sodium channel with Apx and alpha-spectrin in A6 renal epithelial cells.},
  author={Jonathan B. Zuckerman and Xiao Chen and Jonathan D Jacobs and Biao Hu and Thomas R Kleyman and P. R. Smith},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 33},
  pages={23286-95}
}
Recent molecular cloning of the epithelial sodium channel (ENaC) provides the opportunity to identify ENaC-associated proteins that function in regulating its cell surface expression and activity. We have examined whether ENaC is associated with Apx (apical protein Xenopus) and the spectrin-based membrane cytoskeleton in Xenopus A6 renal epithelial cells. We have also addressed whether Apx is required for the expression of amiloride-sensitive Na(+) currents by cloned ENaC. Sucrose density… CONTINUE READING