Association of the dopamine transporter gene (DAT1) core promoter polymorphism -67T variant with schizophrenia.

@article{Khodayari2004AssociationOT,
  title={Association of the dopamine transporter gene (DAT1) core promoter polymorphism -67T variant with schizophrenia.},
  author={N Khodayari and Masoud Garshasbi and Farbod Fadai and Alireza Ostad Rahimi and Leili Hafizi and Ahmad Ebrahimi and Hossein Najmabadi and Mina Ohadi},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2004},
  volume={129B 1},
  pages={10-2}
}
Dysfunction of the central dopaminergic neurotransmission has been suggested to play an important role in the etiology of schizophrenia. The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapses and thereby plays a key role in the regulation of the dopaminergic neurotransmission. In this study, we sought to determine the possible association of the DAT1 gene core promoter polymorphism -67A/T with schizophrenia in a case/control study. The allele and genotype… CONTINUE READING

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