Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.

  title={Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.},
  author={Kate Langley and Lucy Marshall and Marianne B. M. van den Bree and Hollie Victoria Thomas and Michael J. Owen and Michael C. O’Donovan and Anita Thapar},
  journal={The American journal of psychiatry},
  volume={161 1},
OBJECTIVE Association between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a variant (a 48 bp variable number of tandem repeats) in the dopamine D4 receptor gene (DRD4) has been widely documented. A meta-analysis of 21 studies revealed evidence of significant association. In this article the authors examine whether the DRD4 7-repeat allele is associated with performance on a variety of neuropsychological tasks in children with ADHD. METHOD The presence or absence… 

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Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder.

The DRD4 7-repeat allele, which is widely associated with a diagnosis of ADHD, and in this cohort with better clinical outcome, is associated with cortical thinning in regions important in attentional control.

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These data point to improved cognitive functions and prefrontal control in the 7 repeat carriers, probably due to the D4 receptor's modulatory role in prefrontal areas.

The dopamine receptor D4 7-repeat allele influences neurocognitive functioning, but this effect is moderated by age and ADHD status: An exploratory study

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The results might indicate that the effect of the DRD4 7-repeat allele on neuropsychological functioning is dependent on age and ADHD status.

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Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.

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Evidence of positive selection acting at the human dopamine receptor D4 gene locus

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Association of DRD4 in children with ADHD and comorbid conduct problems.

T analysis, which had previously yielded negative results for the total sample, showed evidence of association between DRD4 and "ADHD with conduct problems" (7 repeat allele-24 transmissions, 13 non-transmissions; one-tailed P=0.05).

Deficient inhibition as a marker for familial ADHD.

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