Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.

@article{Langley2004AssociationOT,
  title={Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.},
  author={Kate Langley and Lucy Marshall and Marianne B. M. van den Bree and Hollie Victoria Thomas and Michael J. Owen and Michael C. O’Donovan and Anita Thapar},
  journal={The American journal of psychiatry},
  year={2004},
  volume={161 1},
  pages={
          133-8
        }
}
OBJECTIVE Association between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a variant (a 48 bp variable number of tandem repeats) in the dopamine D4 receptor gene (DRD4) has been widely documented. A meta-analysis of 21 studies revealed evidence of significant association. In this article the authors examine whether the DRD4 7-repeat allele is associated with performance on a variety of neuropsychological tasks in children with ADHD. METHOD The presence or absence… 

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The results might indicate that the effect of the DRD4 7-repeat allele on neuropsychological functioning is dependent on age and ADHD status.

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The results did not confirm the negative effect of the 7-repeat allele on attention problems and externalizing behavior measured on quantitative scales, but found elevated problem scores in the absence of the7- repeat allele.

Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.

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...

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