Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin.

@article{Spratt2011AssociationOT,
  title={Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin.},
  author={Donald E Spratt and Gary S. Shaw},
  journal={Journal of molecular biology},
  year={2011},
  volume={407 3},
  pages={425-38}
}
Cell division cycle protein 34 (CDC34) is a key E2 ubiquitin (Ub)-conjugating enzyme responsible for the polyubiquitination of proteins controlling the G1/S stages of cell division. The acidic C-terminus of the enzyme is required for this function, although there is little structural information providing details for a mechanism. One logical time point involving the C-terminus is the CDC34-Ub thiolester complex that precedes Ub transfer to a substrate. To examine this, we used a CDC34-Ub… CONTINUE READING

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