Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block.

@article{Anjos2004AssociationOT,
  title={Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block.},
  author={Suzana M. Anjos and M J Tessier and Constantin Polychronakos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 12},
  pages={6257-65}
}
A recent study mapped the known association of type 1 diabetes with the cytotoxic T lymphocyte-associated antigen 4 gene to a polymorphism at the 3'end (+6230G>A), but could not rule out additional contribution from the 5' end of the gene. To examine this possibility, we analyzed four polymorphisms at the 5'-flanking region for effects independent of +6230G>A. We confirm, by the transmission disequilibrium test, in 496 family trios overtransmission of the susceptibility allele (G) at +6230 (217… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

CTLA4 and Diabetes

  • Y Ban, M Taniyama, +4 authors Kasuga
  • J Clin Endocrinol Metab,
  • 2004

Similar Papers

Loading similar papers…