Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.

@article{Frodl2007AssociationOT,
  title={Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.},
  author={Thomas Frodl and Cornelius Schuele and Gisela Schmitt and Christine Born and Thomas C. Baghai and Peter Zill and Ronald Bottlender and Rainer Rupprecht and Brigitta Bondy and Maximilian Reiser and Hans-J{\"u}rgen M{\"o}ller and Eva M. Meisenzahl},
  journal={Archives of general psychiatry},
  year={2007},
  volume={64 4},
  pages={410-6}
}
CONTEXT Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression. OBJECTIVE To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects. DESIGN Cross-sectional comparison between patients and controls. SETTING Inpatients with major depression from the Department of Psychiatry and Psychotherapy and healthy… CONTINUE READING
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