Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis

Abstract

Multiple genetic factors contribute to susceptibility to rheumatoid arthritis (RA). The extent of variability in disease presentation in RA may be related to genetic heterogeneity. In this study we investigated the association of the TNF gene polymorphism at position +489 with susceptibility to and severity of RA. Analysis of the frequency of the +489 A and… (More)
DOI: 10.1038/sj.gene.6363632

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