Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

@article{Ueda2003AssociationOT,
  title={Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease},
  author={Hironori Ueda and Joanna M. M. Howson and Laura Esposito and Joanne M. Heward and Snook and Giselle Chamberlain and Daniel B. Rainbow and Kara M D Hunter and Annabel N. Smith and Gianfranco di Genova and Mathias Herr and Ingrid Dahlman and Felicity Payne and Deborah J. Smyth and Christopher E Lowe and Rebecca C. J. Twells and Sarah K. Howlett and Barry C. Healy and Sarah Nutland and Helen E. Rance and Vincent H. Everett and Luc J. Smink and Alex C. Lam and Heather J. Cordell and Neil M. Walker and Cristina Bordin and John S Hulme and Costantino Motzo and Francesco Cucca and John F. Hess and M. L. Metzker and Jane Rogers and Simon G. Gregory and Amit Allahabadia and Ratnasingam Nithiyananthan and Eva Tuomilehto-Wolf and Jaakko Tuomilehto and Polly J. Bingley and Kathleen M. Gillespie and Dag Erik Undlien and Kjersti S R{\o}nningen and Cristian Guja and Constantin Ionescu-Tirgoviste and David A. Savage and Alexander P. Maxwell and Dennis J. Carson and Christopher C. Patterson and Jayne A. Franklyn and David Clayton and Laurence B. Peterson and Linda S. Wicker and John A. Todd and Stephen C. L. Gough},
  journal={Nature},
  year={2003},
  volume={423},
  pages={506-511}
}
Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)—which encodes a vital negative regulatory molecule of the immune system—as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes. In humans, disease susceptibility was… 

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  • 2011
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TLDR
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...

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