Association of the T‐786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects

@article{Safarinejad2011AssociationOT,
  title={Association of the T‐786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects},
  author={Mohammad Reza Safarinejad and Alireza Khoshdel and Babak Shekarchi and Arsia Taghva and Shiva Safarinejad},
  journal={BJU International},
  year={2011},
  volume={107}
}
What's known on the subject? and What does the study add? 

eNOS [Glu298Asp] polymorphism, erectile function and ocular pressure in type 2 diabetes

Eur J Clin Invest 2012; 42 (7): 729–737

The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men

In contrast to Glu298Asp, statistically significant differences in genotypic frequencies of Intron 4 VNTR gene polymorphism between ED and control subjects was established.

Association between NOS3 G894T, T-786C and 4a/4b Variants and Coronary Artery Diseases in Iranian Population

G894T, T-786C and 4a/4b variants were not associated with risk for CAD and occurrence of angiography-assessed stenosis in Northern Iranian population (P>0.05); these alleles might be population-specific and not to be associated with their corresponding gene pool.

Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

The meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.

The association of eNOS G894T polymorphism with metabolic syndrome and erectile dysfunction.

The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNos G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.

Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction

Evidence is shown that eNOS polymorphisms affect the responses of PED and clinical ED patients to sildenafil, and these polymorphisms were more common in GR than in PR patients with clinical ED.

Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis.

The eNOS polymorphisms G894T, 4 VNTR, and T786C were associated with an increased risk for ED, and further studies based on different confounders and using a large population size should be conducted to generate more accurate and reliable conclusions.

Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response

This review explores beyond the cardiovascular area, including drugs regardless of their clinical indications, and finds a trend for loss-of-function alleles, that predispose to higher risk for disease, associating with better clinical response across different drug classes and clinical settings.

References

SHOWING 1-10 OF 29 REFERENCES

The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms.

It was found that aging, diabetes mellitus (DM), and eNOS 894T allele carrier gene polymorphism were the three independently common risk factors for both ED and BPH/LUTS in the Taiwanese population.

Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population.

eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.

Logistic regression analysis showed that G894T polymorphism was an independent risk factor for ED, and significant differences in allelic and genotypic frequencies between patients and controls for the G 894T eNOS polymorphisms were found.

Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease: Meta-Analysis of 26 Studies Involving 23028 Subjects

Findings support the proposal that common genetic variations in the eNOS gene contribute to atherosclerosis susceptibility, presumably by effects on endothelial NO availability.

Plasma Nitric Oxide Concentrations and Nitric Oxide Synthase Gene Polymorphisms in Coronary Artery Disease

The E298D polymorphism of the ecNOS gene was associated with increased plasma NOx in patients with coronary artery disease and was higher in hypertensive CAD patients than in normotensive CAD Patients and controls.

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.

Findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.

The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction.

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