Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study.

@article{Russo2001AssociationOT,
  title={Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study.},
  author={Giuseppina T Russo and James B. Meigs and L. Adrienne Cupples and Serkalem Demissie and James D. Otvos and Peter W. F. Wilson and Carlos Lahoz and Domenico Cucinotta and Patrick Couture and Tracy Mallory and Ernst J. Schaefer and Jos{\'e} M. Ordov{\'a}s},
  journal={Atherosclerosis},
  year={2001},
  volume={158 1},
  pages={173-81}
}
Apolipoprotein (apo) CIII participates in the regulation of the metabolism of triglyceride-rich lipoproteins and it is a major component of chylomicrons and VLDL. The APOC3 gene is on chromosome 11q23 and is highly polymorphic. The less common allele (S2) of the SstI polymorphism on the 3' untranslated region of the APOC3 gene has been previously associated with increased triglycerides, total cholesterol (TC), and apoCIII levels and cardiovascular risk on several, but not all, studies. The aim… CONTINUE READING