Association of the Src Family Tyrosine Kinase Fyn with TrkB

@article{Iwasaki1998AssociationOT,
  title={Association of the Src Family Tyrosine Kinase Fyn with TrkB},
  author={Y Iwasaki and Brigitte Gay and Kazuyo Wada and Shinichi Koizumi},
  journal={Journal of Neurochemistry},
  year={1998},
  volume={71}
}
Abstract: Fyn tyrosine kinase, a member of the Src family, was recently reported to be present in neurons and glia cells. We investigated whether Fyn is involved in the Trk‐dependent signal transduction pathways of neurotrophin. The Fyn‐Src homology domain 2 (SH2) was observed to associate in vitro with the intracellular domain of TrkB (ICD‐TrkB). This association was dependent on the autophosphorylation of ICD‐TrkB. The Fyn‐SH2 domains bound to phosphorylated ICD‐TrkB (plCD‐TrkB) with an… Expand
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