Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

@article{RozakisAdcock1992AssociationOT,
  title={Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases},
  author={Maria Rozakis-Adcock and J. A. McGlade and Geraldine M. Mbamalu and Guiliana Pelicci and Roger J. Daly and Wen-hong Li and Andreas Batzer and Simmy Thomas and Joan S. Brugge and Pier Giuseppe Pelicci and Joseph Schlessinger and Tony J. Pawson},
  journal={Nature},
  year={1992},
  volume={360},
  pages={689-692}
}
THE mammalian shc gene encodes two overlapping, widely expressed proteins of 46 and 52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a more amino-terminal glycine/proline-rich region1. These shc gene products (Shc) are transforming when overexpressed in fibroblasts1. Shc proteins become phosphorylated on tyrosine in cells stimulated with a variety of growth factors1, and in cells transformed by v-src (ref. 2), suggesting that they are tyrosine kinase… CONTINUE READING
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