Association of the Precursor of Interleukin-1β and Peritoneal Inflammation-Role in Pathogenesis of Endometriosis.

@article{Sikora2016AssociationOT,
  title={Association of the Precursor of Interleukin-1β and Peritoneal Inflammation-Role in Pathogenesis of Endometriosis.},
  author={Justyna Sikora and Aleksandra Mielczarek-Palacz and Zdzisława Kondera-Anasz},
  journal={Journal of clinical laboratory analysis},
  year={2016},
  volume={30 6},
  pages={831-837}
}
BACKGROUND The most important proinflammatory cytokine is interleukin (IL)-1β, however its precursor, prointerleukin-1β (proIL-1β), can also potentiate inflammatory state. The aim of this study was to explore the involvement of proIL-1β in pathogenesis of endometriosis. For this purpose, we evaluated concentrations of proIL-1β, IL-1β, and soluble IL-1 receptor type 2 (sIL-1R2) in peritoneal fluid (PF) and macrophage culture medium of women with endometriosis. METHODS PF from 55 women with and… CONTINUE READING