Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis.

@article{Gourh2006AssociationOT,
  title={Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis.},
  author={Pravitt Gourh and Filemon K. Tan and Shervin Assassi and Chul Woo Ahn and Terry Ann McNearney and Michael Fischbach and F. C. Arnett and Maureen D. Mayes},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 12},
  pages={3945-53}
}
OBJECTIVE To determine any associations of the PTPN22 R620W single-nucleotide polymorphism (SNP) with systemic sclerosis (SSc) or with anticentromere antibody (ACA)-positive or anti-topoisomerase I (anti-topo I) antibody-positive SSc, in a case-control study of US white, black, Hispanic, and Choctaw Indian individuals. METHODS A total of 850 white, 130 black, 120 Hispanic, and 20 Choctaw Indian patients with SSc were compared with 430 white, 164 black, 146 Hispanic, and 76 Choctaw Indian… CONTINUE READING

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