Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis

@article{Song2014AssociationOT,
  title={Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis},
  author={Gwan Gyu Song and Sang-Cheol Bae and Youngseop Lee},
  journal={Clinical Rheumatology},
  year={2014},
  volume={33},
  pages={1715-1724}
}
  • Gwan Gyu Song, Sang-Cheol Bae, Youngseop Lee
  • Published in Clinical Rheumatology 2014
  • Medicine
  • The aim of this study was to explore whether the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase (MTHFR) play a role in methotrexate (MTX) toxicity in rheumatoid arthritis (RA). MEDLINE and EMBASE database searches and subsequent manual searches were utilized to identify articles in which C677T and A1298C MTHFR polymorphisms were evaluated in RA patients taking MTX. A meta-analysis was conducted to identify associations between MTHFR polymorphisms and MTX toxicity. Twelve… CONTINUE READING

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