Association of the MAPT locus with Parkinson's disease.

  title={Association of the MAPT locus with Parkinson's disease.},
  author={Christian Wider and Carles Vilari{\~n}o-G{\"u}ell and Barbara Jasińska-Myga and Michael G Heckman and Alexandra I. Soto-Ortolaza and Stephanie A. Cobb and Jan O Aasly and John Mark Gibson and Timothy Lynch and Ryan J. Uitti and Zbigniew K Wszolek and Matthew John Farrer and Owen A. Ross},
  journal={European journal of neurology},
  volume={17 3},
BACKGROUND AND PURPOSE Whilst an association between the tau gene (MAPT)-containing H1 haplotype and supranuclear gaze palsy (PSP) has long been recognized, the effect of H1 on risk for Parkinson's disease (PD) has remained more contentious. METHODS Herein, we examined the association of H1 and PD in three Caucasian PD patient-control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping two H1/H2 single nucleotide polymorphisms (SNPs) in MAPT (rs1052553) and in the… CONTINUE READING


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