Association of the M3151 variant in the transient receptor potential vanilloid receptor-1 (TRPV1) gene with type 1 diabetes in an Ashkenazi Jewish population.

@article{Sadeh2013AssociationOT,
  title={Association of the M3151 variant in the transient receptor potential vanilloid receptor-1 (TRPV1) gene with type 1 diabetes in an Ashkenazi Jewish population.},
  author={Menachem Sadeh and Benjamin Glazer and Zohar Landau and Julio Wainstein and Tall Bezaleli and Ron Dabby and Aaron Hanukoglu and Mona Boaz and Esther Leshinsky-Silver},
  journal={The Israel Medical Association journal : IMAJ},
  year={2013},
  volume={15 9},
  pages={477-80}
}
BACKGROUND Type 1 diabetes in humans is an autoimmune disease in which Tcells target pancreatic islets of Langerhans, leading to the progressive destruction of the insulin-producing beta cells. Both genetic and environmental factors contribute to the development of autoimmune diabetes. The non-obese diabetic (NOD) mouse model of human type 1 diabetes demonstrates two missense mutations in the transient receptor potentialvanilloid receptor-1 (TRPVi) gene. OBJECTIVES To investigate whether… CONTINUE READING

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