Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.

Abstract

CONTEXT ATP-sensitive potassium channels are composed of pore-forming (Kir6.x) and regulatory sulfonylurea receptor (SURx) subunits and have been implicated in the maintenance of glucose homeostasis. Kir6.2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic… (More)
DOI: 10.1210/jc.2008-0543

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