Association of the K153R polymorphism in the myostatin gene and extreme longevity

  title={Association of the K153R polymorphism in the myostatin gene and extreme longevity},
  author={Nuria Garatachea and Tom{\'a}s Pinos and Yolanda C{\'a}mara and Gabriel Rodr{\'i}guez-Romo and Enzo Emanuele and Giovanni Ricevuti and Letizia Venturini and Alejandro Santos-Lozano and Catalina Santiago-Dorrego and Carmen Fiuza-Luces and Thomas Yvert and Antoni L. Andreu and Alejandro Luc{\'i}a},
The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. mammalian target of rapamycin. We compared allele/genotype distributions of the exonic MSTN variants K153R (rs1805086), E164K (rs35781413), I225T and P198A, in Spanish centenarians (cases, n = 156; 132 women, age range 100–111 years) and younger adults (controls, n = 384; 167… CONTINUE READING
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