Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis.

@article{Prots2006AssociationOT,
  title={Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis.},
  author={Iryna Prots and Alla L. Skapenko and Joerg Wendler and Stefan Mattyasovszky and Clarisse L R P Yone and Bernd M. Spriewald and Harald Burkhardt and R. M. Rau and Joachim. R. Kalden and Peter E Lipsky and Hendrik Schulze-Koops},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 5},
  pages={1491-500}
}
OBJECTIVE To examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, or radiographic progression in, rheumatoid arthritis (RA). METHODS The contribution of 2 SNPs (I50V and Q551R) in the coding region of IL4R to RA susceptibility was analyzed by allele-specific polymerase chain reaction in a case-control study of 471 RA patients and 371 healthy controls. Patients with available radiographs of the hands and feet obtained 2… CONTINUE READING

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