Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis.

@article{Matsuoka2008AssociationOT,
  title={Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis.},
  author={Takeshi Matsuoka and Takuya Matsushita and Manabu Osoegawa and Yuji Kawano and Motozumi Minohara and Futoshi Mihara and Yasuharu Nishimura and Yasumasa Ohyagi and J i Kira},
  journal={Multiple sclerosis},
  year={2008},
  volume={14 9},
  pages={1181-90}
}
BACKGROUND In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. METHOD Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser… CONTINUE READING

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