Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum.

@article{Sprong2003AssociationOT,
  title={Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum.},
  author={Hein Sprong and Sophie Degroote and Tommy Nilsson and Masao Kawakita and Nobuhiro Ishida and Peter van der Sluijs and Gerrit van Meer},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 8},
  pages={
          3482-93
        }
}
UDP-galactose reaches the Golgi lumen through the UDP-galactose transporter (UGT) and is used for the galactosylation of proteins and lipids. Ceramides and diglycerides are galactosylated within the endoplasmic reticulum by the UDP-galactose:ceramide galactosyltransferase. It is not known how UDP-galactose is transported from the cytosol into the endoplasmic reticulum. We transfected ceramide galactosyltransferase cDNA into CHOlec8 cells, which have a defective UGT and no endogenous ceramide… CONTINUE READING

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