Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data

@article{Munafo2008AssociationOT,
  title={Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data},
  author={Marcus Robert Munafo and Binnaz Yalcin and Saffron A.G. Willis-Owen and Jonathan Flint},
  journal={Biological Psychiatry},
  year={2008},
  volume={63},
  pages={197-206}
}
BACKGROUND Two variants in the dopamine D4 receptor (DRD4) gene have been reported to be associated with human approach-related traits such as novelty seeking and extraversion. However, the strength of evidence for this association remains uncertain. METHODS We conducted a meta-analysis of published studies of the association between the DRD4 gene variable number of tandem repeats (VNTR) and C-521T polymorphisms and human approach-related personality traits, including novelty seeking… Expand
Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects
TLDR
The results suggest that minor 5-repeat allele is associated with high novelty-seeking scores in healthy Japanese subjects and the DRD4 VNTR polymorphism and TCI scores among the groups are compared. Expand
Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met
TLDR
Evidence is provided of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous meta-analysis, and several direct and indirect moderators are identified to explain contradictory results. Expand
The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness
TLDR
The results suggest that the interaction between dopaminergic and serotonergic genes might underlie impulsiveness and stress the importance of considering novelty seeking as a heterogeneous trait with its subscales having different genetic backgrounds. Expand
The Dopamine D4 Receptor (DRD4) Exon 3 VNTR Contributes to Adaptive Personality Differences in an Italian Small Island Population
The search for evolutionary forces shaping the diversity of human personality traits encouraged studies that have found that islanders are relatively closed and introverted, with little interest inExpand
The association of 5-HTTLPR and DRD4 VNTR polymorphisms with affective temperamental traits in healthy volunteers.
TLDR
This study showed a possible association between the DRD4 polymorphism and certain affective temperaments in the Korean male population and the clarification of the biological basis of predisposing temperaments such as cyclothymic temperament might help to understand the pathophysiology and mechanisms of mood disorders. Expand
Effect of dopamine receptor D4 (DRD4) haplotypes on general psychopathology in patients with eating disorders.
TLDR
Certain combinations of DRD4 variants may contribute to psychopathological features in BN patients, and functional polymorphisms and haplotypes in the Dopamine Receptor D4 (DRD4) gene are determined. Expand
GENETIC STUDY: The dopamine D4 Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
TLDR
Results suggest that the effects of DRD4 VNTR genotype on problematic alcohol use among heavy‐drinking young adults were partially mediated by novelty seeking, which may help elucidate the specific pathways of risk associated with genetic influences on alcohol use and abuse phenotypes. Expand
Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis
  • H. Ujike, T. Katsu, +10 authors S. Kuroda
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2009
TLDR
Findings revealed that genetic variants of DRD2, but not DRD3 or DRD4, confer individual risks for rapid onset, prolonged duration, and spontaneous relapse of methamphetamine psychosis. Expand
Dopamine D4 Receptor Exon III Polymorphism, Adverse Life Events and Personality Traits in a Nonclinical German Adult Sample
TLDR
The results indicate gender-specific influences of the DRD4 gene on human behavior and invite researchers to further investigate gene-environment correlations on personality traits. Expand
Association between the dopamine D4 receptor gene exon III variable number of tandem repeats and political attitudes in female Han Chinese
TLDR
The results provided evidence for a role of the DRD4 gene variants in contributing to individual differences in political attitude particularly in females and more generally suggested that associations between individual genes, and neurochemical pathways, contributing to traits relevant to the social sciences can be provisionally identified. Expand
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TLDR
The data do not provide evidence for a role of DRD4 exon III and the –521C/T polymorphism in the modulation of novelty seeking and extraversion, and these findings are in line with several earlier studies which have failed to replicate the initial association results. Expand
Non‐association of dopamine D4 and D2 receptor genes with personality in healthy individuals
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The present results do not provide evidence that the DRD2 and DRD4 receptor genes contribute a common and relevant effect to personality traits, and in associating the genotypes ofDRD2 with TCI scales, there is no association. Expand
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TLDR
The results provide further confirmation for the role of the DRD4 exon III polymorphism in modulation of Novelty Seeking, and the pattern of associations between the polymorphism and other scales suggests that this polymorphism has its effect on exploratory, extravagant, and extraverted, rather than on impulsive and monotony-avoidant subtypes of novelty Seeking. Expand
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TLDR
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TLDR
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Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population
  • Heon-Jeong Lee, H. Lee, +7 authors Sangduk Kim
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
TLDR
It was found that the interaction between the two alleles of DRD4 polymorphism, 48‐bp VNTR and −521 C/T, were significantly high on NS and persistence personality scores, suggesting that the variants ofDRD4 gene influence the NS and P (persistent) personality traits. Expand
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TLDR
The dopamine D4 receptor gene is probably not of importance to the different personality dimensions as measured by the Karolinska Scales of Personality, but there was a tendency in the direction of the proposed association. Expand
Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking
TLDR
Evidence continues to support a modest role for the long alleles of the dopamine D4 receptor repeat polymorphism in the determination of NS behavior at least in some population groups. Expand
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.
TLDR
It is concluded that the most likely explanation of these results is that the DRD4 VNTR does not influence directly the trait of novelty seeking, in these samples. Expand
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TLDR
A homogeneous study population of 190 healthy male students of middle European descent, aged between 20 and 30 years using Cloninger's TPQ, found that no association between the long repeat of the DRD4-exon-III polymorphism and NS and between the 5HT2c receptor polymorphisms and reward dependence was found, but a significant interaction effect ofDRD4 and 5 HT2cceptor polymorphisms on Reward dependence was observed. Expand
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