Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data

  title={Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data},
  author={Marcus Robert Munafo and Binnaz Yalcin and Saffron A.G. Willis-Owen and Jonathan Flint},
  journal={Biological Psychiatry},
The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness
The results suggest that the interaction between dopaminergic and serotonergic genes might underlie impulsiveness and stress the importance of considering novelty seeking as a heterogeneous trait with its subscales having different genetic backgrounds.
The Dopamine D4 Receptor (DRD4) Exon 3 VNTR Contributes to Adaptive Personality Differences in an Italian Small Island Population
It is suggested that emigration might have caused gene flow out the island that resulted in somewhat unpredictable changes in the frequencies of specific alleles, thus influencing islander personality traits.
The association of 5-HTTLPR and DRD4 VNTR polymorphisms with affective temperamental traits in healthy volunteers.
GENETIC STUDY: The dopamine D4 Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
Results suggest that the effects of DRD4 VNTR genotype on problematic alcohol use among heavy‐drinking young adults were partially mediated by novelty seeking, which may help elucidate the specific pathways of risk associated with genetic influences on alcohol use and abuse phenotypes.
Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients
Two polymorphisms in genes responsible for dopaminergic transmission, which might be implicated in the scores of personality traits measured by the NEO-FFI test, are analyzed and associations open new possibilities for addiction research.
A meta-analytic evaluation of the endophenotype hypothesis: effects of measurement paradigm in the psychiatric genetics of impulsivity.
This meta-analysis compares the magnitude of genetic effects associated with phenotypes at different levels of analysis and finds that neurobiological phenotypes were most susceptible to bias and inflation, raising questions about the validity of reported effects.
Chimpanzee Extraversion scores vary with epigenetic modification of dopamine receptor gene D2 (DRD2) and early rearing conditions.
Investigation of the role of epigenetic modification of the dopamine receptor D2 gene (DRD2) as a potential mechanism underlying personality variation in 51 captive chimpanzees showed that DRD2 methylation is most strongly associated with Extraversion, and that varying methylation levels at specific DRD 2 sites are associated with changes in Extraversion in nursery-reared, but not mother-rearing, individuals.


Lack of Association between Polymorphisms of the Dopamine D4 Receptor Gene and Personality
The data do not provide evidence for a role of DRD4 exon III and the –521C/T polymorphism in the modulation of novelty seeking and extraversion, and these findings are in line with several earlier studies which have failed to replicate the initial association results.
Non‐association of dopamine D4 and D2 receptor genes with personality in healthy individuals
The present results do not provide evidence that the DRD2 and DRD4 receptor genes contribute a common and relevant effect to personality traits, and in associating the genotypes ofDRD2 with TCI scales, there is no association.
Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of Novelty Seeking in a German population
The results provide further confirmation for the role of the DRD4 exon III polymorphism in modulation of Novelty Seeking, and the pattern of associations between the polymorphism and other scales suggests that this polymorphism has its effect on exploratory, extravagant, and extraverted, rather than on impulsive and monotony-avoidant subtypes of novelty Seeking.
The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking.
D4DR genotypes are determined in two groups of Finnish subjects and it is suggested that D4DR may require re-evaluation as a candidate gene for personality variation.
Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population
  • Heon-Jeong LeeH. Lee Sangduk Kim
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
It was found that the interaction between the two alleles of DRD4 polymorphism, 48‐bp VNTR and −521 C/T, were significantly high on NS and persistence personality scores, suggesting that the variants ofDRD4 gene influence the NS and P (persistent) personality traits.
Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking
Evidence continues to support a modest role for the long alleles of the dopamine D4 receptor repeat polymorphism in the determination of NS behavior at least in some population groups.
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.
It is concluded that the most likely explanation of these results is that the DRD4 VNTR does not influence directly the trait of novelty seeking, in these samples.
Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests.
A homogeneous study population of 190 healthy male students of middle European descent, aged between 20 and 30 years using Cloninger's TPQ, found that no association between the long repeat of the DRD4-exon-III polymorphism and NS and between the 5HT2c receptor polymorphisms and reward dependence was found, but a significant interaction effect ofDRD4 and 5 HT2cceptor polymorphisms on Reward dependence was observed.
Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait
A contribution of dopamine D4 receptor availability to individual differences in Novelty Seeking behavior is suggested.