Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma.

@article{Venza2010AssociationOT,
  title={Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma.},
  author={Mario Venza and Teresa Catalano and Maria Visalli and Isabella Venza and Maria Lentini and Maria Cristina Curia and Renato Mariani-Costantini and Diana Teti},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 6},
  pages={1719-25}
}
DSS1 and p53 are required for homologous recombination, but, although p53 inactivation has a key function in skin tumorigenesis, there is no clear evidence supporting a function of DSS1. We screened the entire DSS1 coding sequence and p53 exons 5-8 in a series of 60 cases of skin squamous cell carcinoma (SCC). Mutational analysis of p53 revealed tumor-associated mutations in 28 (46.7%) of the cases. No tumor-associated DSS1 mutations were detected; however, the germline DSS1 c.143G>A synonymous… CONTINUE READING