Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.

@article{Zhao2012AssociationOT,
  title={Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.},
  author={Zhujiang Zhao and Can Li and Yunwei Song and Qunying Wu and Fengchang Qiao and Hong Fan},
  journal={Oncology letters},
  year={2012},
  volume={3 2},
  pages={
          450-454
        }
}
The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control subjects, and to explore the association of the DNMT3A functional SNP, -448A>G, with genetic susceptibility to CRC. Genomic DNA was extracted from samples of 258 patients with CRC… CONTINUE READING
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