Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.

@article{Astier1997AssociationOT,
  title={Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.},
  author={Anne L Astier and Serge N. Mani{\'e} and Susan F. Law and Timothy P. Canty and N Haghayghi and Brain J Druker and Ravi Salgia and Erica A Golemis and Arnold Stephen Freedman},
  journal={Leukemia & lymphoma},
  year={1997},
  volume={28 1-2},
  pages={
          65-72
        }
}
CrkL, a cellular homologue of the v-crk oncogene, belongs to the family of adaptor proteins, containing SH2 and SH3 domains, but no catalytic domain. Stimulation of normal B-cells and B-cell lines through beta1 integrin or - cell antigen receptor (BCR) promoted the association of CrkL with a set of 105-130 kD tyrosine phosphorylated substrates. The principal substrate is a recently identified molecule known as p105HEF1 (HEF1), which is highly homologous to p130Cas (Cas), the major tyrosine… CONTINUE READING
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