Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women

@article{Yamada2001AssociationOT,
  title={Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-$\beta$1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women},
  author={Yoshiji Yamada and A. Miyauchi and Y. Takagi and Masashi Tanaka and M. Mizuno and A. Harada},
  journal={Journal of Molecular Medicine},
  year={2001},
  volume={79},
  pages={149-156}
}
Transforming growth factor-β1 is an important local regulator of bone metabolism, acting downstream of estrogen and cooperatively with vitamin D. The possible association of a C–509→T polymorphism in the promoter region of the transforming growth factor-β1 gene, alone or in combination with a T869→C (Leu10→Pro) polymorphism, with bone mineral density and genetic susceptibility to osteoporosis was investigated in 625 postmenopausal Japanese women. The frequencies of the CC, CT, and TT genotypes… Expand
Tests of linkage and/or association of TGF-β1 and COL1A1 genes with bone mass
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