Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women

@article{Yamada2001AssociationOT,
  title={Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-$\beta$1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women},
  author={Yoshiji Yamada and Akimitsu Miyauchi and Yasuyuki Takagi and Masashi Tanaka and Masashi Mizuno and Atsushi Harada},
  journal={Journal of Molecular Medicine},
  year={2001},
  volume={79},
  pages={149-156}
}
Transforming growth factor-β1 is an important local regulator of bone metabolism, acting downstream of estrogen and cooperatively with vitamin D. The possible association of a C–509→T polymorphism in the promoter region of the transforming growth factor-β1 gene, alone or in combination with a T869→C (Leu10→Pro) polymorphism, with bone mineral density and genetic susceptibility to osteoporosis was investigated in 625 postmenopausal Japanese women. The frequencies of the CC, CT, and TT genotypes… 

Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis.

Combined genotyping of the C-509-->T and T869-->C polymorphisms may prove beneficial in the prevention of osteoporosis in postmenopausal Japanese women, which has provided insight into the function of transforming growth factor-beta1 as well as into the role of genetic factors in the development of bone mineral density.

Association of T869C gene polymorphism of transforming growth factor-β1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women.

It is concluded that T869C polymorphism of the TGF-β1 gene has an impact on decreased serum TGF -β1 levels and influences susceptibility to osteopenia/osteoporosis in Thai women.

A single nucleotide polymorphism in the TGF-β1 gene (rs1982073 C>T) may contribute to increased risks of bone fracture, osteoporosis, and osteoarthritis: a meta-analysis

Findings show that TGF-β1 rs1982073 C>T has a modest effect in increasing susceptibility to bone fracture, OP, and OA.

Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients

The data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.

Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients.

It is concluded that promoter region (-509C>T) and exon 1 (869T>C) polymorphisms are not associated with OPLL in the Korean population.

Association of a polymorphism of the CC chemokine receptor-2 gene with bone mineral density.

The possible association of the 190G-->A (Val64Ile) polymorphism of the CC chemokine receptor-2 gene (CCR2) with bone mineral density (BMD) was examined and CCR2 may be a new candidate for a susceptibility locus for bone mass in middle-aged men and postmenopausal women.

Association between transforming growth factor-beta 1 gene single nucleotide polymorphisms and knee osteoarthritis susceptibility in a Chinese Han population

The TGF-β1 rs1982073 T to C change and the variant C genotype may contribute to knee OA risk in the Chinese Han population.

Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel

A significant association was seen between QUS Stiffness Index (QUS-SI) and the SNP at codon 10 and the linked promoter SNP, C-509T, which is consistent with a gene-dose effect in this cohort of young healthy Caucasian females.
...

References

SHOWING 1-10 OF 27 REFERENCES

Association of a Polymorphism of the Transforming Growth Factor‐β1 Gene with Genetic Susceptibility to Osteoporosis in Postmenopausal Japanese Women

  • Yoshiji YamadaA. Miyauchi K. Ikeda
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1998
The results suggest that the T/C polymorphism of the TGF‐β1 gene is one of the genetic determinants of bone mass and that theT allele is an independent risk factor for the genetic susceptibility to osteoporosis in postmenopausal Japanese women.

Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 gene

A novel G→T polymorphism in a regulatory region of COLIA1 at a recognition site for the transcription factor Sp17 that is significantly related to bone mass and osteoporotic fracture is described.

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.

The COLIA1 polymorphism is associated with reduced bone density and predisposes women to osteoporotic fractures.

Association of transforming growth factor beta1 genotype with spinal osteophytosis in Japanese women.

The T29-->C polymorphism of the TGFbeta1 gene exhibited inverse patterns of association with genetic susceptibility to spinal osteophytosis and with osteoporosis, although radiographic evaluation of osteophytes might not reflect the actual disease severity.

Association of Transforming Growth Factor β1 Genotype with Therapeutic Response to Active Vitamin D for Postmenopausal Osteoporosis

  • Yoshiji YamadaA. Harada M. Shiraki
  • Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2000
Results suggest that TGF‐β1 genotype is associated with both the rate of bone loss and the response to active vitamin D treatment in postmenopausal Japanese women.

Prediction of bone density from vitamin D receptor alleles

It is shown that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals.

Genetic control of the circulating concentration of transforming growth factor type beta1.

In a study of 170 pairs of female twins, it is shown that the concentration of active plus acid-activatable latent TGF-beta1 [(a+l) T GF-beta therefore is predominantly under genetic control, and it is possible that predisposition to atherosclerosis, bone diseases or various forms of cancer may be correlated with the presence of particular alleles at the TGFB1 locus.

Haplotypes of angiotensinogen in essential hypertension.

The haplotype combining the M235T and G-6A polymorphisms appears as the ancestral allele of the human AGT gene and as the one associated with hypertension.

Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Témoin de l'Infarctus du Myocarde (ECTIM) Study.

Since the Pro25 allele was associated with an increased risk of myocardial infarction and a reduced risk of hypertension, it is recommended to favor a cautious interpretation of these apparently inconsistent results.

Association of Bone Mineral Density with Apolipoprotein E Phenotype

  • M. ShirakiY. Shiraki Y. Ouchi
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1997
The Apo E4 allele is associated with a low bone mass in postmenopausal Japanese women and is a significant, independent predictor of the Z score of the lumbar BMD.