Association of the APOE epsilon4 allele with disease activity in multiple sclerosis.

@article{Evangelou1999AssociationOT,
  title={Association of the APOE epsilon4 allele with disease activity in multiple sclerosis.},
  author={N. Evangelou and Matthew C. Jackson and David Beeson and Jackie Palace},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1999},
  volume={67 2},
  pages={203-5}
}
OBJECTIVES Allelic variants of the APOE gene are known to influence the course of many neurological diseases and there is increasing evidence that apolipoprotein E (APOE) is a pivotal component in reinnervation and dendritic remodelling after neuronal injury. Previous studies did not show significant differences in the APOE allele frequencies in multiple sclerosis compared with controls but did not examine for correlation with disease severity. This study explores the relation of APOE genotypes… CONTINUE READING

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