Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad.

@article{Ehlers2007AssociationOT,
  title={Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad.},
  author={Cindy L Ehlers and Karelia Montane-Jaime and Shelly Moore and Samuel Shafe and Roma Joseph and Lucinda G. Carr},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 2},
  pages={216-20}
}
BACKGROUND Two of the class I alcohol dehydrogenase (ADH) genes located on chromosome 4 (ADH1B and ADH1C) encode for multiple isozymes that differ in their kinetic properties. At the ADH1B locus, 3 polymorphisms are present (ADH1B(*)1, ADH1B(*)2, ADH1B(*)3). ADH1B(*)2 (found mostly in individuals of East Asian and Jewish descent) and ADH1B(*)3 (found mostly in individuals of African decent) alleles encode for a more active enzyme variants than ADH1B(*)1 and the presence of these alleles has… CONTINUE READING