Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists.

@article{Babaolu2005AssociationOT,
  title={Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists.},
  author={Melih Onder Babaoğlu and Banu Bayar and A Sukru Aynacioglu and Reinhold Kerb and H{\"u}seyin Abali and I. Celik and Atila Bozkurt},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={78 6},
  pages={619-26}
}
BACKGROUND Resistance to antiemetic treatment with 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonists is still a major problem resulting in patient discomfort and poor compliance to chemotherapy. We hypothesized that clinical resistance to 5-HT(3) antagonists is associated with the single-nucleotide polymorphism (3435C>T) in the gene that codes for the drug efflux transporter adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1). METHODS Patients with cancer (N = 216… CONTINUE READING

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