Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism.

@article{Blum1991AssociationOT,
  title={Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism.},
  author={K. Blum and E. Noble and P. Sheridan and O. Finley and A. Montgomery and T. Ritchie and T. Ozkaragoz and R. J. Fitch and F. Sadlack and D. Sheffield},
  journal={Alcohol},
  year={1991},
  volume={8 5},
  pages={
          409-16
        }
}
In a blinded study, 159 subjects composed of nonalcoholics (N = 43), less severe alcoholics (N = 44), severe alcoholics (N = 52) and young children of alcoholics (CoAs, N = 20) were studied for their allelic association with the D2 dopamine receptor (D2DR) gene utilizing peripheral lymphocytes as the DNA source. The combined alcoholic group compared to the nonalcoholic group showed a significantly greater association with the A1 allele of the D2DR gene. Furthermore, an even more robust… Expand
204 Citations
The D2 dopamine receptor gene: A review of association studies in alcoholism
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