Association of terminal deoxynucleotidyl transferase with Ku.

  title={Association of terminal deoxynucleotidyl transferase with Ku.},
  author={Kiran N. Mahajan and Lisa Gangi-Peterson and David H. Sorscher and Jinzhi Wang and Karen N. Gathy and Nupam P. Mahajan and Westley H. Reeves and Beverly S. Mitchell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 24},
Terminal deoxynucleotidyl transferase (TdT) catalyzes the addition of nucleotides at the junctions of rearranging Ig and T cell receptor gene segments, thereby generating antigen receptor diversity. Ku is a heterodimeric protein composed of 70- and 86-kDa subunits that binds DNA ends and is required for V(D)J recombination and DNA double-strand break (DSB) repair. We provide evidence for a direct interaction between TdT and Ku proteins. Studies with a baculovirus expression system show that TdT… CONTINUE READING


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