Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

@article{Hom2008AssociationOS,
  title={Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.},
  author={Geoffrey Hom and Robert R. Graham and Barmak Modrek and Kimberly E. Taylor and Ward Ortmann and Sophie Garnier and Annette T. Lee and Sharon A. Chung and Ricardo C. Ferreira and P. V. Krishna Pant and Dennis G. Ballinger and Roman Kosoy and Fatma Yesim Demirci and M. Ilyas Kamboh and Amy H. Kao and Chao Tian and Iva Gunnarsson and Anders A. Bengtsson and Solbritt Rantap{\"a}{\"a}-dahlqvist and Michelle A Petri and Susan Manzi and Michael F. Seldin and Lars R{\"o}nnblom and Ann-Christine Syv{\"a}nen and Lindsey A. Criswell and Peter K. Gregersen and Timothy W. Behrens},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 9},
  pages={
          900-9
        }
}
BACKGROUND Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. METHODS We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples from 1311 case subjects with SLE and 1783 control subjects; all subjects were… CONTINUE READING

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