Association of soluble endotoxin receptor CD14 and mortality among patients undergoing hemodialysis.

@article{Raj2009AssociationOS,
  title={Association of soluble endotoxin receptor CD14 and mortality among patients undergoing hemodialysis.},
  author={Dominic S. C. Raj and Vallabh O. Shah and Mehdi Rambod and Csaba Pal Kovesdy and Kamyar Kalantar-Zadeh},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2009},
  volume={54 6},
  pages={1062-71}
}
BACKGROUND CD14 is a key molecule in innate immunity that mediates cell activation and signaling in response to endotoxin and other bacterial wall-derived components. CD14 protein exists in soluble (sCD14) and membrane-bound forms. The correlates of sCD14 in persons undergoing long-term hemodialysis (HD) therapy are not known. We hypothesized that increased sCD14 levels in HD patients are associated with proinflammatory cytokine activation and increased mortality. STUDY DESIGN Cohort study… CONTINUE READING