Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer.


BACKGROUND Cigarette smoking has been associated with microsatellite instability in sporadic colon cancer. Most microsatellite-unstable colon cancers have widespread methylation of CpG islands (i.e., the CpG island methylator phenotype [CIMP]), and many of these tumors harbor the V600E BRAF mutation. We investigated whether the association between smoking… (More)


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