Association of small Rho GTPases and actin ring formation in epithelial cells during the invasion by Candida albicans.

@article{Atre2009AssociationOS,
  title={Association of small Rho GTPases and actin ring formation in epithelial cells during the invasion by Candida albicans.},
  author={Ashwini N Atre and Sachin V. Surve and Yogesh S Shouche and Jomon Joseph and Milind Shivaji Patole and Rajendra L. Deopurkar},
  journal={FEMS immunology and medical microbiology},
  year={2009},
  volume={55 1},
  pages={74-84}
}
Invasion of epithelial cells is a major virulence determinant of Candida albicans; however, the molecular events that occur during invasion are not discerned. This study is aimed to elucidate the role of the host's actin remodeling and involvement of small GTPases during invasion. Actin filaments formed a rigid ring-like structure in the rabbit corneal epithelial cell line SIRC after C. albicans invasion. During invasion, an increase in the mRNA content of Cdc42, Rac1 and RhoA GTPase was… CONTINUE READING

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