Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn’s disease in a British population

@article{Aithal2001AssociationOS,
  title={Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn’s disease in a British population},
  author={G Aithal and C B Day and Julian L B Leathart and A Daly and Mark Falco Sanders Hudson},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={44-47}
}
Interleukin-4 (IL-4) is an important cytokine in mucosal immunity and plays a critical role in the development of colitis inT-α cell receptor mutant mice. Functionally significant polymorphisms have been described in the genes encoding IL-4 and IL-4 receptor. To examine the role of these polymorphisms in disease susceptibility 98 patients with ulcerative colitis, 86 patients with Crohn’s disease and 321 healthy controls were genotyped for polymorphisms at position −34 in the IL-4 gene and codon… CONTINUE READING