Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities

@article{Maintz2011AssociationOS,
  title={Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities},
  author={Laura Maintz and C.-F. Yu and Elke Rodriguez and Hansj{\"o}rg Baurecht and Thomas Bieber and Thomas Illig and Stephan Weidinger and Natalija Novak},
  journal={Allergy},
  year={2011},
  volume={66}
}
To cite this article: Maintz L, Yu C‐F, Rodríguez E, Baurecht H, Bieber T, Illig T, Weidinger S, Novak N. Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy 2011; 66: 893–902. 

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A simple genetic test is proposed using blood samples that would allow identification of DAO alleles associated with altered DAO activity and predisposition to inflammatory bowel disease.

Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity

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Nonsynonymous ABP1 gene polymorphisms are common in humans; they cause relevant functional effects and can be considered as major determinants of variability for human diamine oxidase activity.

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Single nucleotide polymorphisms of genes encoding the histamine degrading enzymes diamine oxidase and histamine N-methyltransferase are analyzed to find possible associations of certain polymorphic markers with the development of diseases where alterations in histamine metabolism have been described.

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TLDR
Since histamine has been implicated as a mediator of inflammatory and neoplastic processes, it was asked whether any of the known polymorphisms of genes encoding HNMT and DAO might be associated with an increased risk of developing inflammatory or neoplastics intestinal diseases.

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Investigation of the possible association between HNMT polymorphism and the risk for migraine found one of these single nucleotide polymorphisms causes the amino acid substitution Thr105Ile, related to decreased enzyme activity.

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Elevated plasma histamine in pigs acts as a pathogenetic factor for the disease manifestation, and the trias of variables shown in this study should be consequently investigated in man.

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The results contradict the current opinion that oral histamine intake in food is not clinically relevant, especially since many commonly used drugs are DAO-inhibitors and approximately 20% of the authors' population take these drugs.