Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms.

@article{Hoebee2003AssociationOS,
  title={Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms.},
  author={Barbara Hoebee and Edwin Rietveld and Louis J. Bont and M. Oosten and Hennie M. Hodemaekers and Nico J. D. Nagelkerke and Herman J Neijens and Jan L. L. Kimpen and Tjeerd G. Kimman},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={187 1},
  pages={2-11}
}
The association of variants of genes encoding interleukin (IL)-4 and the IL-4 receptor alpha chain (IL-4Ralpha) with respiratory syncytial virus (RSV) bronchiolitis was examined in hospitalized infants. Polymorphisms in IL-4 (C-590T) and IL-4Ralpha (I50V and Q551R) were genotyped by restriction fragment-length polymorphism analysis. Control subjects included parents of the hospitalized children (for the transmission/disequilibrium test), and a random population sample (for the case-control… CONTINUE READING