Association of serum vitamin B12 levels with stage of liver fibrosis and treatment outcome in patients with chronic hepatitis C virus genotype 1 infection: a retrospective study

@article{Mechie2015AssociationOS,
  title={Association of serum vitamin B12 levels with stage of liver fibrosis and treatment outcome in patients with chronic hepatitis C virus genotype 1 infection: a retrospective study},
  author={Nicolae-Catalin Mechie and Armin D Goralzcyk and Lars Reinhardt and Sabine Mihm and Ahmad Amanzada},
  journal={BMC Research Notes},
  year={2015},
  volume={8}
}
BackgroundChronic hepatitis C (CHC) is a global health challenge. New therapeutic agents with excellent sustained virological response (SVR) rates are available mainly in developed countries, while the majority of CHC patients live in countries with low health budget. Predictors of therapeutic response are therefore necessary. Vitamin B12 appears to be involved in hepatitis C virus replication.MethodsWe therefore studied retrospectively the relationship between baseline serum vitamin B12 levels… Expand
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References

SHOWING 1-10 OF 154 REFERENCES
High Predictability of a Sustained Virological Response (87%) in Chronic Hepatitis C Virus Genotype 1 Infection Treatment by Combined IL28B Genotype Analysis and γ-Glutamyltransferase/Alanine Aminotransferase Ratio: A Retrospective Single-Center Study
TLDR
The pretreatment γ-GT/ALT ratio significantly enhances the predictability of the IL28B genotype and will help to identify patients who will most likely benefit from an interferon-α-based combination therapy in a nontriaged ordinary setting. Expand
Serum B12 levels predict response to treatment with interferon and ribavirin in patients with chronic HCV infection
TLDR
S‐B12 is independently correlated to ETR in HCV patients treated with interferon and ribavirin, which suggests that B12 is involved in suppression of viral replication during anti‐HCV treatment. Expand
Insulin Resistance Predicts Rapid Virologic Response to Peginterferon/Ribavirin Combination Therapy in Hepatitis C Genotype 4 Patients
TLDR
IR is a major determinant of both RVR and SVR in genotype 4 CHC patients, and would seem to be a useful tool for predicting the response to therapy. Expand
Vitamin D status and serum ferritin concentration in chronic hepatitis C virus type 1 infection
The circulating 25‐hydroxylated form of vitamin D3, 25(OH)D, and serum ferritin concentrations have been described to be associated with disease progression in chronic hepatitis C. Both parametersExpand
Associations between serum lipids and hepatitis C antiviral treatment efficacy
TLDR
Serum lipids are associated with SVR, although these paramaters did not explain the racial difference in treatment response, and the results are compatible with proposed biological mechanisms of HCV entry, replication, and secretion and may underscore new potential therapeutic targets for HCV eradication. Expand
Vitamin B 12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus
Background In vitro, vitamin B12 acts as a natural inhibitor of hepatitis C virus (HCV) replication. Objective To assess the effect of vitamin B12 on virological response in patients with chronic HCVExpand
Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus
TLDR
Vitamin B12 supplementation significantly improves SVR rates in HCV-infected patients naïve to antiviral therapy as well as easy-to-treat HCV genotypes. Expand
Treatment predictors of a sustained virologic response in hepatitis B and C.
TLDR
After initiation of treatment, initial viral decline with undetectable HCV-RNA at week 4 of therapy (RVR) is the best predictor of sustained virologic response independent of HCV genotype. Expand
Ratio of serum gamma-GT/ALT rather than ISDR variability is predictive for initial virological response to IFN-alpha in chronic HCV infection.
TLDR
The ratio of serum gamma-GT/ALT in combination with HCV genotype, however, was found to be a more reliable and stringent predictive parameter. Expand
Definition and management of anemia in patients infected with hepatitis C virus
TLDR
Viramidine, a liver‐targeting prodrug of Ribavirin has the potential to maintain the virologic efficacy of ribavirin while decreasing the risk of hemolytic anemia in patients with chronic hepatitis C. Expand
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