Association of serum autoantibodies to tumor-suppressor gene p53 in patients with ovarian cancer according to status of the disease.

@article{Marx1997AssociationOS,
  title={Association of serum autoantibodies to tumor-suppressor gene p53 in patients with ovarian cancer according to status of the disease.},
  author={Dagmar Marx and Thomas E. Uebel and Alfred Schauer and Walther Christian Kuhn and Harald Meden},
  journal={Oncology reports},
  year={1997},
  volume={4 6},
  pages={1157-60}
}
Sera from 130 ovarian cancer patients and from 118 normal control volunteers were assayed for serum autoantibodies to p53 using an enzyme-linked immunosorbent assay (ELISA). Overall, autoantibodies were detected in 41% of ovarian cancer patients as compared to 0.9% of healthy individuals (P<0.001). The incidence of autoantibodies was lower in patients with complete remission (20%) as compared to those with recurrence (48%, P<0.01) and before primary surgery (49%, P<0.05). There was no… CONTINUE READING

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