Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients.

@article{Contreras2010AssociationOS,
  title={Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients.},
  author={Javier Contreras and Sandra Hernandez and Paulina Quezada and Albana M Dassori and Consuelo Walss-Bass and Michael Escamilla and Henriette Ravent{\'o}s},
  journal={Journal of neurogenetics},
  year={2010},
  volume={24 2},
  pages={83-9}
}
Depression and suicidal behavior are frequently observed in patients with schizophrenia. The serotonin transporter protein regulates serotonergic signaling at synapses and is encoded by a single gene (SLC6A4; Locus Link ID: 6532), located at 17q11.1-q12 with two polymorphic variants (the short and the long allele). The short allele of serotonin transporter gene has been associated with depression and suicidality in individuals who suffered negative life events and with depression in individuals… CONTINUE READING