Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study

@article{Siitonen2006AssociationOS,
  title={Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study},
  author={Niina Siitonen and Leena Pulkkinen and Ursula Mager and Jaana Lindstr{\"o}m and Johan G Eriksson and Timo T. Valle and Helena H{\"a}m{\"a}l{\"a}inen and Pirjo Ilanne-Parikka and Sirkka Kein{\"a}nen-Kiukaanniemi and Jaakko Tuomilehto and Markku Laakso and Matti Uusitupa},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={1795-1805}
}
Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the association of ADIPOR1 gene variations with body size and risk of type 2 diabetes in subjects with impaired glucose tolerance, who participated in the Finnish Diabetes Prevention Study (DPS). We… CONTINUE READING