Association of protein kinase C activation with induction of ornithine decarboxylase in murine but not human keratinocyte cultures.

@article{Fischer1993AssociationOP,
  title={Association of protein kinase C activation with induction of ornithine decarboxylase in murine but not human keratinocyte cultures.},
  author={Susan M. Fischer and Mark L. Lee and R E Maldve and Rebecca J. Morris and David Trono and David L Burow and Andrew P. Butler and Amy I Pavone and B K Warren},
  journal={Molecular carcinogenesis},
  year={1993},
  volume={7 4},
  pages={228-37}
}
The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity. Keratinocytes from adult CD-1 mice and from discarded adult human skin were grown in primary culture in a high-calcium serum-free… CONTINUE READING
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