Association of prostate cancer with vitamin D receptor haplotypes in African-Americans.

  title={Association of prostate cancer with vitamin D receptor haplotypes in African-Americans.},
  author={Sue Ann Ingles and Gerhard A. Coetzee and R K Ronald K Ross and Brian E. Henderson and Laurence N. Kolonel and Laura E. Crocitto and Wei Wang and Robert W Haile},
  journal={Cancer research},
  volume={58 8},
In previous studies, allelic variation in the 3' end of the vitamin D receptor gene was associated with increased risk of prostate cancer in white men. Several polymorphisms, including a BsmI restriction site and a poly(A) microsatellite, can be used interchangeably to mark the unidentified locus in whites. In African-Americans, however, these markers are not interchangeable, due to weaker linkage disequilibrium in this genomic region in this population. Here, we genotyped both the BsmI and… CONTINUE READING


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